EGF-02380 Green

O=C(N1CCOCC1)N1CCN(c2ncc(C(F)(F)F)cc2Cl)CC1
0.560
Platform Score
2D Structure
EGF-02380
C15H18ClF3N4O2 | Exact mass: 378.107
Key Metrics
N/A
Vina (kcal/mol)
#-
Docking Rank
1
Hinge Binder
49
TPSA
379
MW
0
HBD
2.3
SlogP
Display Controls
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EGFR Docking Result
N/A
kcal/mol (molecular docking)
Docking Rank#- of 1,249
Consensus Score-
ReceptorEGFR (PDB: 1M17)
Selective No
Selectivity Profile
ADMET Profile
BBB (BOILED-Egg) BBB- (non-penetrant)
ADMET Status Pass (no hard fails)
CNS Drug-Likeness
Physicochemical Properties
Molecular Weight378.80 Da
TPSA48.9 A^2
HBD0
HBA4
SlogP2.33
Fsp30.600
Rotatable Bonds1
Rings3 (1 aromatic)
QED0.752
SA Score2.36 (1=easy, 10=hard)
CNS MPO- / 4.0
FormulaC15H18ClF3N4O2
Exact Mass378.107
Classification
Scaffold (Murcko)-
Source Versions-
Best Source Score-
Best Source Rank#-
Hinge Binder 4-Aminoquinazoline Hinge
InChIKey-
Filter PassYes