EGF-05215 Red

O=C(Nc1cnc2[nH]c(-c3cccc(C4(O)CCOCC4)c3)nc2c1)Nc1ccccc1OC(F)F
0.231
Platform Score
2D Structure
EGF-05215
C25H23F2N5O4 | Exact mass: 495.1718
Key Metrics
N/A
Vina (kcal/mol)
#-
Docking Rank
0
Hinge Binder
121
TPSA
496
MW
4
HBD
4.9
SlogP
Display Controls
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EGFR Docking Result
N/A
kcal/mol (molecular docking)
Docking Rank#- of 1,249
Consensus Score-
ReceptorEGFR (PDB: 1M17)
Selective No
Selectivity Profile
ADMET Profile
BBB (BOILED-Egg) BBB- (non-penetrant)
ADMET Status Pass (no hard fails)
CNS Drug-Likeness
Physicochemical Properties
Molecular Weight495.50 Da
TPSA121.4 A^2
HBD4
HBA6
SlogP4.87
Fsp30.240
Rotatable Bonds6
Rings5 (4 aromatic)
QED0.303
SA Score2.86 (1=easy, 10=hard)
CNS MPO- / 4.0
FormulaC25H23F2N5O4
Exact Mass495.1718
Classification
Scaffold (Murcko)-
Source Versions-
Best Source Score-
Best Source Rank#-
Hinge Binder Not present
InChIKey-
Filter PassYes