EGF-06272 Red

O=C(O)COc1ccc(Cl)cc1C1CCCCN1C(=O)NCc1ccc(N2CC(F)(F)C2)nc1
0.345
Platform Score
2D Structure
EGF-06272
C23H25ClF2N4O4 | Exact mass: 494.1532
Key Metrics
N/A
Vina (kcal/mol)
#-
Docking Rank
1
Hinge Binder
95
TPSA
495
MW
2
HBD
4.1
SlogP
Display Controls
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EGFR Docking Result
N/A
kcal/mol (molecular docking)
Docking Rank#- of 1,249
Consensus Score-
ReceptorEGFR (PDB: 1M17)
Selective No
Selectivity Profile
ADMET Profile
BBB (BOILED-Egg) BBB- (non-penetrant)
ADMET Status Pass (no hard fails)
CNS Drug-Likeness
Physicochemical Properties
Molecular Weight494.90 Da
TPSA95.0 A^2
HBD2
HBA5
SlogP4.09
Fsp30.435
Rotatable Bonds7
Rings4 (2 aromatic)
QED0.602
SA Score3.11 (1=easy, 10=hard)
CNS MPO- / 4.0
FormulaC23H25ClF2N4O4
Exact Mass494.1532
Classification
Scaffold (Murcko)-
Source Versions-
Best Source Score-
Best Source Rank#-
Hinge Binder 4-Aminoquinazoline Hinge
InChIKey-
Filter PassYes