EGF-07210 Red

COc1cccc(F)c1-c1cc[nH]c(=Nc2ccc(NCCO)cn2)n1
0.360
Platform Score
2D Structure
EGF-07210
C18H18FN5O2 | Exact mass: 355.1445
Key Metrics
N/A
Vina (kcal/mol)
#-
Docking Rank
1
Hinge Binder
95
TPSA
355
MW
3
HBD
2.3
SlogP
Display Controls
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EGFR Docking Result
N/A
kcal/mol (molecular docking)
Docking Rank#- of 1,249
Consensus Score-
ReceptorEGFR (PDB: 1M17)
Selective No
Selectivity Profile
ADMET Profile
BBB (BOILED-Egg) BBB- (non-penetrant)
ADMET Status Pass (no hard fails)
CNS Drug-Likeness
Physicochemical Properties
Molecular Weight355.40 Da
TPSA95.4 A^2
HBD3
HBA6
SlogP2.26
Fsp30.167
Rotatable Bonds6
Rings3 (3 aromatic)
QED0.630
SA Score3.08 (1=easy, 10=hard)
CNS MPO- / 4.0
FormulaC18H18FN5O2
Exact Mass355.1445
Classification
Scaffold (Murcko)-
Source Versions-
Best Source Score-
Best Source Rank#-
Hinge Binder 4-Aminoquinazoline Hinge
InChIKey-
Filter PassYes