EGF-07232 Red

COc1ccc(C(=O)c2sc3nc(N4CCOCC4)c4c(c3c2N)CC(C)(C)OC4)cc1OC
0.348
Platform Score
2D Structure
EGF-07232
C25H29N3O5S | Exact mass: 483.1828
Key Metrics
N/A
Vina (kcal/mol)
#-
Docking Rank
1
Hinge Binder
96
TPSA
484
MW
1
HBD
3.8
SlogP
Display Controls
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EGFR Docking Result
N/A
kcal/mol (molecular docking)
Docking Rank#- of 1,249
Consensus Score-
ReceptorEGFR (PDB: 1M17)
Selective No
Selectivity Profile
ADMET Profile
BBB (BOILED-Egg) BBB- (non-penetrant)
ADMET Status Pass (no hard fails)
CNS Drug-Likeness
Physicochemical Properties
Molecular Weight483.60 Da
TPSA96.1 A^2
HBD1
HBA9
SlogP3.81
Fsp30.440
Rotatable Bonds5
Rings5 (3 aromatic)
QED0.547
SA Score2.80 (1=easy, 10=hard)
CNS MPO- / 4.0
FormulaC25H29N3O5S
Exact Mass483.1828
Classification
Scaffold (Murcko)-
Source Versions-
Best Source Score-
Best Source Rank#-
Hinge Binder 4-Aminoquinazoline Hinge
InChIKey-
Filter PassYes