EGF-07383 Red

CCN1c2ncc(CC(NC(C)=O)c3ccc(F)cc3)cc2C(=O)N(C)c2ccc(Cl)nc21
0.338
Platform Score
2D Structure
EGF-07383
C24H23ClFN5O2 | Exact mass: 467.1524
Key Metrics
N/A
Vina (kcal/mol)
#-
Docking Rank
1
Hinge Binder
78
TPSA
468
MW
1
HBD
4.4
SlogP
Display Controls
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EGFR Docking Result
N/A
kcal/mol (molecular docking)
Docking Rank#- of 1,249
Consensus Score-
ReceptorEGFR (PDB: 1M17)
Selective No
Selectivity Profile
ADMET Profile
BBB (BOILED-Egg) BBB- (non-penetrant)
ADMET Status Pass (no hard fails)
CNS Drug-Likeness
Physicochemical Properties
Molecular Weight467.90 Da
TPSA78.4 A^2
HBD1
HBA5
SlogP4.44
Fsp30.250
Rotatable Bonds5
Rings4 (3 aromatic)
QED0.561
SA Score3.19 (1=easy, 10=hard)
CNS MPO- / 4.0
FormulaC24H23ClFN5O2
Exact Mass467.1524
Classification
Scaffold (Murcko)-
Source Versions-
Best Source Score-
Best Source Rank#-
Hinge Binder 4-Aminoquinazoline Hinge
InChIKey-
Filter PassYes