PLK4 — CNS Oncology (GBM, Medulloblastoma)

BBB-penetrant PLK4 inhibitors for brain tumors

Complete
30,191
Compounds Generated
100
Validated Leads
6.5d
Time to Leads
$0.63
Cost per Lead
-11.84 kcal/mol
Best Docking
63 unique
Scaffold Diversity
0
RL Versions
23.4%
Green Light Rate
Target
GenePLK4
ChEMBL IDCHEMBL4722
PDB4YUR, 6GY2
Pharmacophorec1c[nH]nc1N (Aminopyrazole DAD)
Off-Targets
NameGenePDB
Aurora_AAURKA2C6E
Aurora_BAURKB4AF3
FAKPTK23BZ3
Pipeline Progress
Data Fetch
Oracle Training
Transfer Learning
RL Campaign
Validation
Deliverables
Browse Compounds View Leads